Dr Jack A T Edmonds MB BS FRCGP

Your Health in Our Hands

News & Updates

Booster shot

Booster Shots

Findings from a study of 458 U.S. patients who received booster shots reported by Reuters Health online at Medscape Family Health (US ) on January 28th 2022

The study looked at booster shots using the Pfizer, Moderna ( mRNA vaccines )and Johnson & Johnson vaccines ( J&J similar to Astra Zeneca Oxford vaccine ) and results are published in the New England Journal of Medicine.

When the booster was the same product as the original vaccine, neutralizing antibody titres increased by a factor of 4 to 20, but when a different product was used for the booster, that increased titres by a factor of 6 to 73.

The only combination that didn't result in an increase in spike-specific T-cell responses was among patients who only received the Johnson & Johnson vaccine as primary vaccine and booster.


The “poor” results after primary vaccination with J&J vaccine needs further clarification . J&J vaccine is not available in the UK . In fact when tests on T Cell activation – as opposed to antibody response – post vaccination were undertaken , those who had had primary vaccination with  J&J showed good levels of acquired immunity post booster with mRNA vaccines . All academically interesting but not relevant to us in the UK .

In conclusion the study shows that mixing vaccines may slightly increase the effectiveness of immunization against COVID-19 . That`s good news for people who had AZ first and Pfizer afterwards , Those of us who have had 3 mRNA shots need not worry.


Date posted: 15 February 2022

Disclaimer: We have taken every precaution in making sure that the information contained in these documents is accurate. The nature of the information provided is for your general information only. The content does not constitute legal or other professional advice.


Make Appointment

Health In the News

Monkeypox patients should avoid pet contact
Gerbils, hamsters and other rodents could be particularly susceptible to the disease, warn experts.
Posted: 27 May 2022

Covid infections continue to decline in UK
One in 60 people is infected with the virus, according to the Office for National Statistics.
Posted: 27 May 2022

Unexplained child hepatitis cases rise again in UK
Health officials are investigating a link with a common virus, as well as other factors.
Posted: 27 May 2022

'Daughter's long Covid makes us prisoners in our own home'
Helen Goss calls for more help for children like Anna, 9, who is ill two years after catching Covid.
Posted: 28 May 2022

Scandal-hit Nottingham maternity services ordered to improve
Maternity units, where Sarah Hawkins's baby and dozens of others died, are rated inadequate.
Posted: 27 May 2022

Information source: BBC Health